Cisplatin and aki and autophagy

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August undefined, 2024

WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with … WebAug 17, 2024 · NEW & NOTEWORTHY This study examined how inhibition of autophagy has opposite effects on the development of acute and chronic kidney injury. Autophagy …

Roles of Reactive Oxygen Species and Autophagy in the …

WebDec 7, 2024 · Genetic ablation of the renal tubular (RT) Atg7 gene or pharmacological inhibition of autophagy suppressed the protective effects of HDAC6. Taken together, our study indicates that HDAC6 contributes to ischemia- and cisplatin-induced AKI by inhibiting autophagy and the acetylation of α-tubulin. WebJan 22, 2024 · Cisplatin treatment may activate toll-like receptors 2 in renal tubular cells, which further activates autophagy via the phosphorylate phosphoinositide 3-kinase … sharma global logistics

Mechanisms of Cisplatin-Induced Acute Kidney Injury

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, … WebSep 25, 2024 · (1) Autophagy inhibits inflammatory responses induced in AKI through the regulation of mTOR and AMPK pathways and the inhibition of inflammasomes activation. (2) Autophagy can also help in the regulation of inflammatory responses through the nuclear factor kappa B pathway, which is beneficial to the recovery of kidney tissues. WebFeb 24, 2024 · During autophagy-dependent cell death, extensive vacuolization of the cytoplasm is formed; the integrity of the plasma membrane is lost; and sometimes, enlargement of the Golgi and ER is observed... population of jackson tn 2021

Targeting ferroptosis in acute kidney injury Cell Death & Disease

Special Issue "Autophagy in Tissue Injury and Homeostasis"

WebFeb 2, 2024 · Some scholars have found that in the cisplatin-induced AKI mice, the C. cicadae mycelium extract regulated the inflammatory response by inhibiting renal pathological changes, inflammatory cell infiltration, and the release of a variety of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. WebAug 7, 2024 · Mitophagy is a mechanistically elaborate process including (a) mitophagy initiation, (b) priming of mitochondria for recognition by autophagy machinery, (c) engulfment of the marked mitochondria by formation of the autophagosome, and (d) lysosomal sequestration and hydrolytic degradation ( Figure 1; Vasquez-Trincado et al., … population of ivory coast 2021WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular … sharm a gennaio

"WebApr 7, 2016 · Blockade of either AMPKα activation or autophagy induction could largely abolish the protective effect of metformin in cisplatin-induced cell death. Together, this study demonstrated that metformin may protect against cisplatin-induced tubular cell apoptosis and AKI through stimulating AMPKα activation and autophagy induction in … " - Cisplatin and aki and autophagy

Cisplatin and aki and autophagy

Mechanisms and Functions of Mitophagy and Potential Roles in Renal …

WebJan 10, 2024 · Cisplatin, a chemotherapeutic agent approved by the United States Food and Drug Administration in 1978, is used in the treatment of various solid organ malignancies [ 13 ]. However, ~30% of... WebCisplatin, a chemotherapeutic agent, is a known nephrotoxin and can cause AKI. The cisplatin treatment induces a time-dependent increase in the LC3 expression in proximal tubular epithelial cells. 23 The inhibition of autophagy through either treatment with 3-MA or knockdown of Becn1 by short-hairpin RNA or siRNA, or Atg5 by siRNA resulted in ...

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WebMar 23, 2024 · Here, we postulated that systemically delivered rapamycin perfluorocarbon nanoparticles (PFC NP) could reach the injured kidneys at sufficient and sustained concentrations to mitigate cisplatin-induced acute kidney injury and preserve renal function. Using fluorescence microscopic imaging and fluorine magnetic resonance … WebApr 27, 2024 · Aims:Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial dysfunction. As a major mechanism for cellular self-degradation, autophagy has been proven to protect against cisplatin …

WebNov 30, 2024 · In this study, we investigated whether canagliflozin protects against cisplatin-induced AKI, depending on adenosine monophosphate-activated protein kinase (AMPK) activation and following... WebDec 12, 2024 · Cisplatin can induce AKI through ischemic damage, by reducing the blood flow in the medulla of the kidneys leading to tubular cell injury. Vasoconstriction due to …

WebApr 6, 2024 · Therefore, it is particularly important to find drugs that have therapeutic effect against cisplatin ototoxicity. Autophagy is a cell metabolic process in which cells degrade their components within lysosomes (or vacuoles) to maintain normal physiological activities and homeostasis ( 7 ). WebApr 25, 2014 · The role of autophagy in cisplatin-induced AKI is discussed in the next section. 4.2. Autophagy Autophagy is a cellular process of “self-eating” in which …

WebDec 31, 2024 · Special Issue Information. Dear Colleagues, Autophagy (“auto-digestion”), a lysosome-dependent process, degrades and turnovers damaged or senescent organelles and proteins. Autophagy is a highly-regulated process, which impacts several vital cellular responses, including inflammation, cell death, energy metabolism and organelles ...

WebFeb 18, 2024 · Cisplatin, a platinum-based compound, is a commonly used and highly effective chemotherapeutic agent utilized for the treatment of a variety of solid tumors. … sharma goldson ze li and alexander taamWeb1 day ago · In this study, a natural product from Osage Orange, pomiferin, was identified as a novel autophagy activator that circumvents innate resistance by triggering autophagic cell death via SERCA inhibition and activation of the CaMKKβ-AMPK-mTOR signaling cascade. In addition, pomiferin also directly inhibited the P-gp (MDR1/ABCB1) efflux and ... population of jackson ms 2022WebSep 1, 2014 · Pharmacologic induction of autophagy by administrating the mTOR inhibitor, rapamycin or temsirolimus, facilitated renal recovery from AKI during endotoxemia in aged mice [116,119] and pharmacologic inhibition of autophagy with either bafilomycin or 3-methyladenine enhanced cisplatin-induced renal tubular cell death . sharma graphicsWebAdministration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been … population of jackson holeWebOct 14, 2024 · Cisplatin is an inorganic platinum-based drug that was FDA approved as an anticancer agent in 1978.1It is a standard therapy used to treat many solid organ … sharma group vicenzaWebCisplatin-induced acute kidney injury in mice was established by intraperitoneal injection of cisplatin. The levels of urea nitrogen and creatinine in serum were measured， renal pathology change was assayed by HE staining， qRT-PCR and Western blot were used to detect the expression levels of PIM1 mRNA and PIM1 protein. sharma gold melbourneWebNov 1, 2024 · Toll‐like receptor 2 (TLR2) is constitutively expressed in tubular epithelial cells of the kidney and participates in cisplatin‐induced AKI. The autophagy is a dynamic catabolic process that maintains intracellular homeostasis, which is involved in the pathogenesis of AKI. sharma group world wide srl