Population pharmacokinetics
WebApr 12, 2024 · There is thus an interest in describing tenofovir pharmacokinetics (PK) and its variability in people living with HIV ... . METHODS We conducted a population PK analysis (NONMEM®) on 877 tenofovir and 100 tenofovir alafenamide concentrations measured in 569 PLWH. Model-based simulations allowed prediction of tenofovir trough ... WebJun 29, 2024 · Background: Meropenem is being investigated for repurposing as an anti-tuberculosis drug. This study aimed to develop a meropenem population pharmacokinetics model in patients with pulmonary tuberculosis and identify covariates explaining inter-individual variability.Methods: Patients were randomized to one of four treatment groups: …
Population pharmacokinetics
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WebIn a population-based pharmacokinetic study where data from three different studies in patients with MF and PV were pooled, T ½ was 3.76 h for men and 4.07 h for women. … WebIn a population-based pharmacokinetic study where data from three different studies in patients with MF and PV were pooled, T ½ was 3.76 h for men and 4.07 h for women. Another population pharmacokinetic analysis found CL/F of …
WebJan 1, 2024 · The term population pharmacokinetics has been commonly associated with the analysis of sparse data (few observations per subject with unstructured sampling … Webpopulation pharmacokinetics in Ugandans. Br J Clin Pharmacol. 2009;68(5):690–699. 29. Cabrera SE, Santos D, Valverde MP, et al. Influence of the
WebFeb 13, 2024 · A population pharmacokinetics (PPK) analysis showed that race is a covariate on CL, and that the CL value estimated for the Asian population (1.51 L/h) was ≈36% lower than that for a predominantly White population (2.36 L/h). 10 Similarly, the reported apparent CL/F after a single oral administration of 200-mg equivalent of … WebApr 16, 2024 · The population pharmacokinetics (PK) of rivaroxaban have been evaluated in several population-specific models. We developed an integrated population PK model using pooled data from 4,918 patients in 7 clinical trials across all approved indications.
WebPopulation PK is the science of describing the PK variability within a population and identifying the cause of this variability. This information is important for designing …
WebDec 25, 2024 · Population pharmacokinetics has become a popular method especially in children, due to the potential for sparse sampling, flexible sampling times, computing of … greensboro tech companiesWebDec 5, 2024 · Content updated on July 07, 2024. Population pharmacokinetics (popPK) is the study of variability in drug concentrations within a patient population receiving … fmc shenleyWebMar 1, 2024 · This study aimed to develop a population pharmacokinetic model using full pharmacokinetic (PK) profiles of isoniazid (INH) taking into account demographic and … fmc skyway in sweetwaterWebFeb 28, 2024 · Background The pharmacokinetic variability of ampicillin-sulbactam in adults has not been extensively described, particularly in patients with a reduced renal function (i.e., < 60 mL/min). Objective This study investigated the population pharmacokinetics of ampicillin and sulbactam in patients with a wide range of renal functions and sought to … fmc size chartWebJun 27, 2014 · She has been teaching workshops and graduate courses on population modeling for over 10 years and has published more than 20 articles and book chapters on … fmcs leavelogWebClinical pharmacokinetics (arising from the clinical use of population pharmacokinetics) is the direct application to a therapeutic situation of knowledge regarding a drug's pharmacokinetics and the characteristics of a population that a patient belongs to (or can be ascribed to). greensboro telephone directoryWebMar 17, 2024 · The pharmacokinetics of vancomycin vary among neonates, and we aimed to conduct population pharmacokinetic analysis to determine the optimal dosage of … greensboro tax services